bsm-90042R

DATASHEET

Host: Rabbit

Target Protein: Complement C3

Specificity: Knockdown Validated

Immunogen Range: 850-900/1663

Clonality: Monoclonal

Isotype: IgG

Entrez Gene: 718

Swiss Prot: P01024

Source: A synthesized peptide derived from human C3 / C3a

Purification: Affinity Purified

Storage Buffer: Supplied in PBS (pH 7.4) containing 50% glycerol, and 0.02% sodium azide.

Storage: -20 °C

Background:

C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates. Derived from proteolytic degradation of complement C3, C3a anaphylatoxin is a mediator of local inflammatory process. In chronic inflammation, acts as a chemoattractant for neutrophils (By similarity). It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes.

Cell Line: HeLa

Knockdown technology: shRNA Knockdown

Size: 50 ul Ab + 25ug KD cell Lysate + 25ug WT cell

Concentration: Lot dependent

Predicted Molecular Weight: 187 kDa

Cross Reactive Species: Human

For research use only. Not intended for diagnostic or therapeutic use.