bsm-90026R

DATASHEET

Host: Rabbit

Target Protein: NME/NM23 Nucleoside Diphosphate Kinase 1

Specificity: Knockdown Validated

Immunogen Range: 1-50/152

Clonality: Monoclonal

Isotype: IgG

Entrez Gene: 4830

Swiss Prot: P15531

Source: A synthesized peptide derived from human NM23A

Purification: Affinity Purified

Storage Buffer: Supplied in PBS (pH 7.4) containing 50% glycerol, and 0.02% sodium azide.

Storage: -20 °C

Background:

Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Possesses nucleoside-diphosphate kinase, serine/threonine-specific protein kinase, geranyl and farnesyl pyrophosphate kinase, histidine protein kinase and 3'-5' exonuclease activities. Involved in cell proliferation, differentiation and development, signal transduction, G protein-coupled receptor endocytosis, and gene expression. Required for neural development including neural patterning and cell fate determination. During GZMA-mediated cell death, works in concert with TREX1. NME1 nicks one strand of DNA and TREX1 removes bases from the free 3' end to enhance DNA damage and prevent DNA end reannealing and rapid repair.

Cell Line: HeLa

Knockdown technology: shRNA Knockdown

Size: 50 ul Ab + 25ug KD cell Lysate + 25ug WT cell

Concentration: Lot dependent

Predicted Molecular Weight: 17 kDa

Cross Reactive Species: Human

For research use only. Not intended for diagnostic or therapeutic use.