bsm-90022R

DATASHEET

Host: Rabbit

Target Protein: Galectin 3

Specificity: Knockdown Validated

Immunogen Range: 4-36/250

Clonality: Monoclonal

Isotype: IgG

Entrez Gene: 3958

Swiss Prot: P17931

Source: A synthesized peptide derived from human Galectin 3

Purification: Affinity Purified

Storage Buffer: Supplied in PBS (pH 7.4) containing 50% glycerol, and 0.02% sodium azide.

Storage: -20 °C

Background:

Galactose-specific lectin which binds IgE. May mediate with the alpha-3, beta-1 integrin the stimulation by CSPG4 of endothelial cells migration. Together with DMBT1, required for terminal differentiation of columnar epithelial cells during early embryogenesis (By similarity). In the nucleus: acts as a pre-mRNA splicing factor. Involved in acute inflammatory responses including neutrophil activation and adhesion, chemoattraction of monocytes macrophages, opsonization of apoptotic neutrophils, and activation of mast cells. Together with TRIM16, coordinates the recognition of membrane damage with mobilization of the core autophagy regulators ATG16L1 and BECN1 in response to damaged endomembranes.

Cell Line: HeLa

Knockdown technology: shRNA Knockdown

Size: 50 ul Ab + 25ug KD cell Lysate + 25ug WT cell

Concentration: Lot dependent

Predicted Molecular Weight: 26 kDa

Cross Reactive Species: Human
Mouse
Rat

For research use only. Not intended for diagnostic or therapeutic use.