bsm-90020R

DATASHEET

Host: Rabbit

Target Protein: Poly(RC) Binding Protein 2

Specificity: Knockdown Validated

Immunogen Range: 257-300/365

Clonality: Monoclonal

Isotype: IgG

Entrez Gene: 5094

Swiss Prot: Q15366

Source: A synthesized peptide derived from human PCBP2

Purification: Affinity Purified

Storage Buffer: Supplied in PBS (pH 7.4) containing 50% glycerol, and 0.02% sodium azide.

Storage: -20 °C

Background:

Single-stranded nucleic acid binding protein that binds preferentially to oligo dC. Major cellular poly(rC)-binding protein. Acts as a negative regulator of antiviral signaling. Negatively regulates cellular antiviral responses mediated by MAVS signaling. It acts as an adapter between MAVS and the E3 ubiquitin ligase ITCH, therefore triggering MAVS ubiquitination and degradation. Together with PCBP1, required for erythropoiesis, possibly by regulating mRNA splicing (By similarity).

Cell Line: HeLa

Knockdown technology: shRNA Knockdown

Size: 50 ul Ab + 25ug KD cell Lysate + 25ug WT cell

Concentration: Lot dependent

Predicted Molecular Weight: 34-39 kDa

Cross Reactive Species: Human
Mouse
Rat

For research use only. Not intended for diagnostic or therapeutic use.