bsm-90012R

DATASHEET

Host: Rabbit

Target Protein: Calreticulin

Specificity: Knockdown Validated

Immunogen Range: 45-86/417

Clonality: Monoclonal

Isotype: IgG

Entrez Gene: 811

Swiss Prot: P27797

Source: A synthesized peptide derived from human calreticulin

Purification: Affinity Purified

Storage Buffer: Supplied in PBS (pH 7.4) containing 50% glycerol, and 0.02% sodium azide.

Storage: -20 °C

Background:

Calcium-binding chaperone that promotes folding, oligomeric assembly and quality control in the endoplasmic reticulum (ER) via the calreticulin/calnexin cycle. This lectin interacts transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER. Interacts with the DNA-binding domain of NR3C1 and mediates its nuclear export. Involved in maternal gene expression regulation. May participate in oocyte maturation via the regulation of calcium homeostasis (By similarity). Present in the cortical granules of non-activated oocytes, is exocytosed during the cortical reaction in response to oocyte activation and might participate in the block to polyspermy (By similarity).

Cell Line: HeLa

Knockdown technology: shRNA Knockdown

Size: 50 ul Ab + 25ug KD cell Lysate + 25ug WT cell

Concentration: Lot dependent

Predicted Molecular Weight: 48 kDa

Cross Reactive Species: Human
Mouse
Rat

For research use only. Not intended for diagnostic or therapeutic use.