bsm-90008R

DATASHEET

Host: Rabbit

Target Protein: Diaphanous Related Formin 1

Specificity: Knockdown Validated

Immunogen Range: 1-45/1272

Clonality: Monoclonal

Isotype: IgG

Entrez Gene: 1729

Swiss Prot: O60610

Source: A synthesized peptide derived from human DIAPH1

Purification: Affinity Purified

Storage Buffer: Supplied in PBS (pH 7.4) containing 50% glycerol, and 0.02% sodium azide.

Storage: -20 °C

Background:

Actin nucleation and elongation factor required for the assembly of F-actin structures, such as actin cables and stress fibers (By similarity). Binds to the barbed end of the actin filament and slows down actin polymerization and depolymerization (By similarity). Required for cytokinesis, and transcriptional activation of the serum response factor (By similarity). DFR proteins couple Rho and Src tyrosine kinase during signaling and the regulation of actin dynamics (By similarity). Functions as a scaffold protein for MAPRE1 and APC to stabilize microtubules and promote cell migration (By similarity). Has neurite outgrowth promoting activity. Acts in a Rho-dependent manner to recruit PFY1 to the membrane (By similarity)

.Cell Line: Hela

Knockdown technology: shRNA Knockdown

Size: 50 ul Ab + 25ug KD cell Lysate + 25ug WT cell

Concentration: Lot dependent

Predicted Molecular Weight: 141 kDa

Cross Reactive Species: Human
Mouse
Rat

For research use only. Not intended for diagnostic or therapeutic use.