bsm-70524M

DATASHEET

Host: Mouse

Target Protein: Integrin αL (Extracellular region)

Specificity: The antibody detects a 180 kDa* protein corresponding to the molecular mass of Integrin αL on SDS-PAGE immunoblots of human Jurkat cells.

Clonality: Monoclonal

Isotype: IgG1

Swiss Prot: P20701

Source: Clone M594 was generated from a recombinant protein containing amino acid residues in the extracellular region of human Integrin αL. This sequence has low homology to other integrin family members.

Purification: Purified by Protein A.

Storage Buffer: PBS + 1 mg/ml BSA, 0.05% NaN3 and 50% glycerol

Storage: Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C.

Background:

Integrins are cell adhesion molecules that can mediate bidirectional transfer of signals across the plasma membrane. The cytoplasmic domains of integrin family members interact with components of the signal transduction apparatus within cells. Integrin receptors contain noncovalently associated α and β subunits that consist of a large extracellular region (the ligand-binding domain), a short transmembrane region, and a cytoplasmic domain of varying length. In mammals, at least 17 α subunits and 8 β subunits have been identified and these proteins can heterodimerize to form at least 22 different receptors. The integrin β2 subunit associates with integrin αL to form a receptor for ICAM family members. Integrin β2/αL is involved in a variety of immune phenomena including leukocyte-endothelial cell interaction, cytotoxic T-cell mediated killing, and antibody dependent killing by granulocytes and monocytes.