bsm-70311M

DATASHEET

Host: Mouse

Target Protein: Vimentin

Specificity: Specific for the ~50 kDa Vimentin protein.

Clonality: Monoclonal

Isotype: IgM

Entrez Gene: 7431

Swiss Prot: P08670

Source: Cell nuclei preparation from adult human thymus.

Purification: Protein L purified

Storage Buffer: PBS

Storage: Recommended that the undiluted antibody be aliquoted into smaller working volumes (10-30 uL/vial depending on usage) upon arrival and stored long term at -20° C or -80° C, while keeping a working aliq

Background:

Vimentin is the major protein subunit of the 10 nm or intermediate filaments (IFs) found in many kinds of mesenchymal and epithelial cells as well as developing neuronal and astrocytic precursor cells in the CNS. Vimentin is thought to be critically involved in lymphocyte adhesion and transmigration (Nieminen M et al. 2006). Copolymers are frequently formed between vimentin and other IFs, such as GFAP (in many kinds of astrocytes), desmin (in muscle cells) and neurofilament proteins (in developing neurons). Antibodies to vimentin are useful in studies of stem cells and generally to reveal the filamentous cytoskeleton. Recent studies suggest that vimentin affects prostate cancer cells motility and invasiveness (Zhao et al. 2008).

Size: 100ul

Concentration: Lot Dependent

Predicted Molecular Weight: 50

Cross Reactive Species: Human

For research use only. Not intended for diagnostic or therapeutic use.