bsm-70301M

DATASHEET

Host: Mouse

Target Protein: Tubulin, beta III

Specificity: Specific for endogenous levels of the ~55 kDa beta III tubulin protein. This clone is similar to the monoclonal antibody Tuj1.

Clonality: Monoclonal

Isotype: IgG

Entrez Gene: 246118

Swiss Prot: Q4QRB4

Source: Synthetic peptide corresponding to amino acid residues specific to rat beta III tubulin, conjugated to keyhole limpet hemocyanin (KLH).

Purification: Purified by Protein G.

Storage Buffer: 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 µg per ml BSA and 50% glycerol.

Storage: Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C.

Background:

Tubulin is the major constituent of microtubules, existing as a heterodimer of the α and β subunits. The beta III isoform of tubulin is found almost exclusively in neuronal processes of adult tissues and is therefore an excellent marker for neurons. Neuron specific, posttranslational modifications within the C-terminal domain of beta III tubulin have been shown to be developmentally regulated suggesting that they may serve to modulate the interaction of tubulin with microtubule associated proteins (Lee et al., 1990). Additionally, beta III tubulin has been found to be highly expressed in cancer cells such as small cell lung cancer, large cell neuroendocrine carcinoma and adenocarcinomas and is correlated with an increasing histological degree of malignancy (Katsetos et al., 2003)

Size: 100ul

Concentration: Lot Dependent

Predicted Molecular Weight: 55

Cross Reactive Species: Mouse
Rat

Predicted Cross Reactive Species: Human
Dog
Bovine
Sheep
Horse
Cat
Rabbit
Guinea Pig
Goat
Hamster
Non-Human Primate
Vole

For research use only. Not intended for diagnostic or therapeutic use.