bsm-70277M

DATASHEET

Host: Mouse

Target Protein: Syntaxin

Specificity: Specific for endogenous levels of the ~36 kDa syntaxin protein. The antibody has also been used for immunohistochemistry on formalin fixed, vibratome sections. *Does not work on paraffin sections.

Clonality: Monoclonal

Isotype: IgG1

Entrez Gene: 6804

Swiss Prot: Q16623

Source: Synaptic immunoprecipitate (crude) from human brain.

Purification: Purified by Protein G.

Storage Buffer: 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 µg per ml BSA and 50% glycerol.

Storage: Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C.

Background:

Syntaxins are a family of proteins involved in the docking of synaptic vesicles with the plasma membrane. Syntaxin, along with synaptobrevin and SNAP-25, forms the SNARE complex which mediates synaptic vesicle fusion and exocytosis. Binding of Munc18-1 to the N-terminus of syntaxin 1 has been demonstrated to be essential for exocytic membrane fusion (Khvotchev et al., 2007). Decreased levels of phosphorylated syntaxin 1 in the prefrontal cortex have recently been correlated with schizophrenia (Castillo et al., 2010).

Size: 100ul

Concentration: Lot Dependent

Predicted Molecular Weight: 36

Cross Reactive Species: Human
Rat
Pig
Hamster

For research use only. Not intended for diagnostic or therapeutic use.