bsm-70271M

DATASHEET

Host: Mouse

Target Protein: Synaptobrevin (VAMP)

Specificity: Specific for endogenous levels of the ~16 kDa synaptobrevin. The antibody has also been demonstrated to work in immunohistochemistry on formalin fixed, vibratome sections, but does not work on paraffin sections.

Clonality: Monoclonal

Isotype: IgM

Entrez Gene: 6843

Swiss Prot: P23763

Source: Synaptic immunoprecipitate (crude) from human brain.

Purification: IgM Purified culture supernatant

Storage Buffer: 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 µg per ml BSA and 50% glycerol.

Storage: Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C.

Background:

Synaptobrevin (aka VAMP) is an integral membrane protein of synaptic vesicles that plays a major role in the formation of larger SNARE complexes, along with SNAP-25 and syntaxin. Synaptobrevin has been shown to be essential for two fast synapse-specific membrane trafficking processes: fast exocytosis for neurotransmitter release and fast endocytosis that mediates rapid recycling of synaptic vesicles (Deak et al., 2004). Decreased levels of synaptobrevin in human hippocampus and cortex have been correlated with cognitive deficits in Alzheimer’s disease (Sze et al., 2000).

Size: 100ul

Concentration: Lot Dependent

Predicted Molecular Weight: 16

Cross Reactive Species: Human
Mouse
Rat
Bovine
Pig
Rabbit
Hamster

For research use only. Not intended for diagnostic or therapeutic use.