bsm-70253M

DATASHEET

Host: Mouse

Target Protein: SAP49

Specificity: Specific for endogenous levels of the ~49 kDa SAP49 protein.

Clonality: Monoclonal

Isotype: IgG2b

Entrez Gene: 10262

Swiss Prot: Q15427

Source: Recombinant full length human SAP49 expressed in and purified from E. Coli.

Purification: Purified by Protein G.

Storage Buffer: PBS + 50% glycerol and 5 mm NaN3

Storage: Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C.

Background:

The spliceosome associated protein of ~49 kDa (SAP49), also known as SF3B4, is a widely expressed nuclear splicing factor that has been shown to have RNA binding activity as well as direct interaction with SAP145 (Champion-Arnaud and Reed 1994). The SAP145-SAP49 complex has recently been implicated in cell cycle progression as Vpr (viral protein 1 of HIV-1) has been shown to bind SAP145 thus interfering with the proper formation and functioning of the SAP145-SAP49 complex (Terada and Yasuda 2006).

Size: 100ul

Concentration: Lot Dependent

Predicted Molecular Weight: 49

Cross Reactive Species: Human
Mouse
Rat

For research use only. Not intended for diagnostic or therapeutic use.