bsm-70244M

DATASHEET

Host: Mouse

Target Protein: Retinoic Acid Receptor, α-Isotype

Specificity: Specific for endogenous levels of the ~48 kDa RAR-α isotype.

Clonality: Monoclonal

Isotype: IgG1

Entrez Gene: 5914

Swiss Prot: P10276

Source: Synthetic peptide corresponding to amino acid residues from the N-terminal region of human retinoic acie receptor, α-isotype, conjugated to keyhole limpet hemocyanin (KLH).

Purification: Purified by Protein G.

Storage Buffer: 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 µg per ml BSA and 50% glycerol.

Storage: Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C.

Background:

Retinoic acid (RA; active metabolite of vitamin A) plays a prominent role in regulating the transition of proliferating precursor cells (such as carcinoma cells and neuronal precursors) to postmitotic differentiated cells (Joshi et al., 2005). The retinoid X receptors (RXRs) family (RXRα, β and γ), preferentially bind 9-cis-RA and regulate gene transcription by forming heterodimers with a second family of RA receptors. RAs have been suggested to potentially play a therapeutic role in cervical cancer (Abu et al., 2005). RAs are known to play key roles in neuronal development and an increasing body of evidence indicates that retinoid signaling may regulate synaptic plasticity and associated learning and memory behaviors (Lane and Bailey, 2005).

Size: 100ul

Concentration: Lot Dependent

Predicted Molecular Weight: 48

Cross Reactive Species: Human
Mouse
Rat

Predicted Cross Reactive Species: Dog
Bovine
Guinea Pig

For research use only. Not intended for diagnostic or therapeutic use.