bsm-70201M

DATASHEET

Host: Mouse

Target Protein: Nuclear Pore Complex

Specificity: Specific for endogenous levels of the nuclear pore complex proteins.

Clonality: Monoclonal

Isotype: IgG1

Source: Yeast nuclear preparations

Purification: Concentrated tissue culture supernatant

Storage Buffer: Concentrated tissue culture supernatent + 10 mM NaN3.

Storage: Recommended that the undiluted antibody be aliquoted into smaller working volumes (10-30 uL/vial depending on usage) upon arrival and stored long term at -20° C or -80° C, while keeping a working aliq

Background:

The nuclear pore complex (NPC) is a very large structure made up of at least 50 different proteins that span the double membrane of the nuclear envelope functioning as a gateway for macromolecular traffic between the cytoplasm and the nucleus (Nakielny and Dreyfuss,1999). Discrete nuclear pore complex proteins or nucleoporins such as NUP98, NUP180 and p62 have been implicated in autoimmune disease and cancer. Patients with primary biliary cirrhosis (PBC) frequently produce autoantibodies against p62 and NUP180 (Wilken et al., 1993; Nesher et al., 2001) while NUP98 translocations have been found in patients with acute myelogenous leukemia (AML) (Jaju et al. 2001)

Size: 100ul

Concentration: Lot Dependent

Cross Reactive Species: Human
Mouse
Rat
Bovine
Chicken
Drosophila

For research use only. Not intended for diagnostic or therapeutic use.