bsm-70147M

DATASHEET

Host: Mouse

Target Protein: MeCP2

Specificity: Specific for endogenous levels of the MeCP2 protein. Due to usually high charge, the protein runs at ~75 kDa in SDS-PAGE of mouse brain lysates.

Clonality: Monoclonal

Isotype: IgG2b

Entrez Gene: 4204

Swiss Prot: P51608

Source: Full length human recombinant MeCP2

Purification: Purified by Protein G.

Storage Buffer: PBS + 50% glycerol and 5 mM NaN3

Storage: Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C.

Background:

MeCP2 (Methyl-CpG Binding Protein 2) is a chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair and is not influenced by sequences flanking the methyl-CpGs. MeCP2 has been shown to mediate transcriptional repression through interaction with histone deacetylase and the corepressor SIN3A (Nan et al., 1998). Defects in MeCP2 are the cause of Rett syndrome (RTT) (Amir et al., 1999). RTT is an X-linked dominant disease; it is a progressive neurologic developmental disorder and one of the most common causes of mental retardation in females.

Size: 100ul

Concentration: Lot Dependent

Predicted Molecular Weight: 75

Cross Reactive Species: Human
Mouse
Rat

For research use only. Not intended for diagnostic or therapeutic use.