bsm-70138M

DATASHEET

Host: Mouse

Target Protein: Lamin A/C

Specificity: Specific for endogenous levels of the ~64 kDa and ~74 kDa lamin A and C proteins.

Clonality: Monoclonal

Isotype: IgG1

Entrez Gene: 4000

Swiss Prot: P02545

Source: Recombinant full length human lamin C expressed in and purified from E. Coli.

Purification: Purified by Protein G.

Storage Buffer: PBS + 10 mM NaN3.

Storage: Recommended that the undiluted antibody be aliquoted into smaller working volumes (10-30 uL/vial depending on usage) upon arrival and stored long term at -20° C or -80° C, while keeping a working aliq

Background:

Lamins A and C are nuclear structural proteins that are part of the intermediate filament family and coded for by the same gene (LMNA). Lamins A and C are nearly identical except for their carboxy termini (McKeon et al., 1986). Mutations in the gene encoding lamins A/C have been shown to cause a variety of diseases including autosomal dominant Emery-Dreifuss muscular dystrophy (Bonne et al., 1995), autosomal dominant limbgirdle muscular dystrophy (Muchir et al., 2000) and Charcot-Marie-Tooth disorder type 2 (De Sandre-Giavonnoli et al., 2002).

Size: 100ul

Concentration: Lot Dependent

Predicted Molecular Weight: 64, 74

Cross Reactive Species: Human

For research use only. Not intended for diagnostic or therapeutic use.