bsm-70094M

DATASHEET

Host: Mouse

Target Protein: FTO (Fat mass and obesity related protein)

Specificity: Specific for endogenous levels of the ~58 kDa FTO protein.

Clonality: Monoclonal

Isotype: IgG2a

Entrez Gene: 79068

Swiss Prot: Q9C0B1

Source: Synthetic peptide corresponding to amino acid residues from the N-terminal region of rat FTO, conjugated to keyhole limpet hemocyanin (KLH).

Purification: Purified by Protein G.

Storage Buffer: 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 µg per ml BSA and 50% glycerol.

Storage: Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C.

Background:

The FTO gene is the most robust gene for common obesity characterized to date. FTO gene expression has been found to be significantly upregulated in the hypothalamus of rats after food deprivation and strongly negatively correlated with the expression of orexin peptide which is involved in the stimulation of food intake (Fredricksson R et al., 2008). Deletion analysis of FTO gene in mice showed that FTO is functionally involved in the control of both energy intake and energy expenditure (Fischer J et al., 2009).

Size: 100ul

Concentration: Lot Dependent

Predicted Molecular Weight: 58

Cross Reactive Species: Human
Mouse
Rat

Predicted Cross Reactive Species: Dog
Bovine
Sheep
Non-Human Primate

For research use only. Not intended for diagnostic or therapeutic use.