bsm-70085M

DATASHEET

Host: Mouse

Target Protein: EWS

Specificity: Specific for endogenous levels of the ~85 kDa EWS protein.

Clonality: Monoclonal

Isotype: IgG2b

Entrez Gene: 2130

Swiss Prot: Q01844

Source: Full length recombinant human EWS expressed in and purified from E. coli.

Purification: Purified by Protein G.

Storage Buffer: PBS + 50% glycerol and 5 mm NaN3

Storage: Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C.

Background:

The Ewing Sarcoma Breakpoint Region 1 (EWSR1) gene encodes the EWS protein, which along with FUS and TAF15 comprises the FET family of RNA-binding proteins. EWS is primarily expressed in the nucleus, but has also been found in the cytoplasm of secretory cell types (Andersson et al., 2008). Defects of EWSR1 are known to cause Ewing sarcoma and have been implicated in amyotrophic lateral sclerosis (ALS) (Svetoni et al., 2016). Recently, EWS has been shown to directly interact with oncogenic ETS transcription factors in the promotion of prostate cancer (Kedage et al., 2016).

Size: 100ul

Concentration: Lot Dependent

Predicted Molecular Weight: 85

Cross Reactive Species: Human
Mouse
Rat
Dog

For research use only. Not intended for diagnostic or therapeutic use.