bsm-70044M

DATASHEET

Host: Mouse

Target Protein: COBRA1 (NELF-B)

Specificity: Specific for endogenous levels of the ~62 kDa COBRA1 protein.

Clonality: Monoclonal

Isotype: IgG1

Entrez Gene: 25920

Swiss Prot: Q8WX92

Source: Recombinant full length human COBRA1 purified from E. coli.

Purification: Purified by Protein G.

Storage Buffer: PBS + 0.05% NaN3

Storage: Recommended that the undiluted antibody be aliquoted into smaller working volumes (10-30 uL/vial depending on usage) upon arrival and stored long term at -20° C or -80° C, while keeping a working aliq

Background:

COBRA1 (cofactor of BRCA1) also known as NELF-B, is an essential component of the negative elongation factor (NELF) complex. COBRA1 has been shown to directly bind estrogen receptor alpha (ERα) and repress ERα-mediated transcription (Aiyar SE et al., 2004). COBRA1 has also been demonstrated to interact with c-Jun and c-Fos suggesting a role in modulation of the AP-1 pathway and therefore may be important in cell proliferation, differentiation, apoptosis and oncogenesis (Zhong H et al., 2004)

Size: 100ul

Concentration: Lot Dependent

Predicted Molecular Weight: 62

Cross Reactive Species: Human
Mouse
Rat

For research use only. Not intended for diagnostic or therapeutic use.