bsm-70038M

DATASHEET

Host: Mouse

Target Protein: c-FOS

Specificity: Specific for endogenous levels of the ~50 kDa c-FOS protein.

Clonality: Monoclonal

Isotype: IgG1

Entrez Gene: 2353

Swiss Prot: P01100

Source: Recombinant full length human c-FOS expressed in and purified from E. Coli.

Purification: Purified by Protein G.

Storage Buffer: PBS + 50% glycerol and 5 mM NaN3

Storage: Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C.

Background:

c-FOS is a member of the FOS transcription factor family which forms dimers with c-JUN to produce the Activator Protein 1 (AP-1) complex which plays a key role in critical cellular processes such as cell proliferation, differentiation and apoptosis (Chiu et al., 1988). c-FOS expression has been demonstrated to be a useful marker of neuronal activation as it is rapidly induced following various stimuli (Hoffman et al., 1993). Additionally, c-FOS has been shown to be overexpressed in a variety of malignant tumor types (Milde-Langosch 2005).

Size: 100ul

Concentration: Lot Dependent

Predicted Molecular Weight: 50

Cross Reactive Species: Human
Mouse
Rat
Bovine

For research use only. Not intended for diagnostic or therapeutic use.