bsm-70028M

DATASHEET

Host: Mouse

Target Protein: Calbindin

Specificity: Specific for endogenous levels of the ~28 kDa calbindin protein.

Clonality: Monoclonal

Isotype: IgG2a

Entrez Gene: 793

Swiss Prot: P05937

Source: Recombinant full length human calbindin purified from E. coli.

Purification: Purified by Protein G.

Storage Buffer: PBS + 50% glycerol and 5 mM NaN3

Storage: Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C.

Background:

Calbindin (aka. calbindin D28k) is a member of the calcium-binding protein superfamily that includes calmodulin and troponin C. It is predominantly expressed in certain types of neurons, particularly in dendrites and perikarya of the cerebellum and is thought to buffer entry of calcium upon stimulation of glutamate receptors (Andressen et al., 1993). Calbindin has recently been shown to play a critical role in mitochondrial dysfunction and loss of synaptic proteins in vivo in an Alzheimer’s disease mouse model (Kook et al., 2014).

Size: 100ul

Concentration: Lot Dependent

Predicted Molecular Weight: 28

Cross Reactive Species: Human
Mouse
Rat
Bovine

For research use only. Not intended for diagnostic or therapeutic use.