bsm-70013M

DATASHEET

Host: Mouse

Target Protein: Alpha Synuclein

Specificity: Specific for the endogenous levels of the ~15 kDa alpha synuclein protein.

Clonality: Monoclonal

Isotype: IgG1

Entrez Gene: 6622

Swiss Prot: P37840

Source: Full length human alpha synuclein expressed in E. Coli.

Purification: Purified by Protein G.

Storage Buffer: PBS + 50% glycerol and 5 mm NaN3

Storage: Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C.

Background:

Alpha-synuclein is a presynaptic neuronal protein that is thought to be involved in the formation of SNARE complexes. Most significantly, aggregated alpha-synuclein is one of the major components found in the Lewy bodies that occur in Parkinson’s disease (PD) and other neurodegenerative disorders (Okochi et al., 2000). Early onset Parkinson's disease may be caused by a duplication or triplication of one of the alpha synuclein genes (ChartierHarlin MC et al., 2004 and Singleton, AB et al., 2005). Alpha-synuclein is also found in the Lewy bodies of patients with diffuse Lewy body disease and inclusions in glial cells in the brains of patients with multiple system atrophy (MSA) and amyotrophic lateral sclerosis (ALS).

Size: 100ul

Concentration: Lot Dependent

Predicted Molecular Weight: 15

Cross Reactive Species: Human
Mouse
Rat
Bovine
Pig

For research use only. Not intended for diagnostic or therapeutic use.