bsm-70005M

DATASHEET

Host: Mouse

Target Protein: Alpha II Spectrin

Specificity: Specific for endogenous levels of the ~240 kDa alpha II spectrin protein.

Clonality: Monoclonal

Isotype: IgG1

Entrez Gene: 6709

Swiss Prot: Q13813

Source: Recombinant contstruct containing the 7th, 8th, 9th repeats of human alpha II spectrin.

Purification: Purified by Protein G.

Storage Buffer: PBS + 50% glycerol and 5 mm NaN3

Storage: Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C.

Background:

The spectrin family of cytoskeletal proteins is comprised of 2 alpha genes (α1 and α2) and five beta genes (β1-β5). Spectrins have been shown to function as scaffolding proteins in mechanical support of the plasma membrane as well as bind other membrane proteins and lipids (Bennett and Baines 2001). Defects in spectrin genes have been linked to some forms of hereditary spherocytosis, a type of auto-hemolytic anemia which is characterized by spherical red blood cells that are more prone to lysis (Eber and Lux 2004).

Size: 100ul

Concentration: Lot Dependent

Predicted Molecular Weight: 240

Cross Reactive Species: Human
Mouse
Rat
Bovine

For research use only. Not intended for diagnostic or therapeutic use.