bsm-62587R

DATASHEET

Host: Rabbit

Target Protein: GRK6

Clonality: Monoclonal

Isotype: IgG

Entrez Gene: 2870

Swiss Prot: P43250

Source: KLH conjugated synthetic peptide derived from human GRK6

Purification: Purified by Protein A.

Storage Buffer: 10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol.

Storage: Shipped at 4°. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Background:

Specifically phosphorylates the activated forms of G protein-coupled receptors. Such receptor phosphorylation initiates beta-arrestin-mediated receptor desensitization, internalization, and signaling events leading to their desensitization. Seems to be involved in the desensitization of D2-like dopamine receptors in striatum and chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis.Phosphorylates rhodopsin (RHO) (in vitro) and a non G-protein-coupled receptor: LRP6 during Wnt signaling (in vitro).

Size: 100ul

Concentration: 1ug/ul

Predicted Molecular Weight: 66

Cross Reactive Species: Human
Mouse

For research use only. Not intended for diagnostic or therapeutic use.