bsm-62481R-HRP

DATASHEET

Host: Rabbit

Target Protein: RGMA

Clonality: Recombinant

Isotype: IgG

Entrez Gene: 56963

Swiss Prot: Q96B86

Source: KLH conjugated synthetic peptide derived from human Repulsive guidance molecule A

Purification: Purified by Protein A.

Storage Buffer: Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Storage: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Background:

Member of the repulsive guidance molecule (RGM) family that performs several functions in the developing and adult nervous system. Regulates cephalic neural tube closure, inhibits neurite outgrowth and cortical neuron branching, and the formation of mature synapses. Binding to its receptor NEO1/neogenin induces activation of RHOA-ROCK1/Rho-kinase signaling pathway through UNC5B-ARHGEF12/LARG-PTK2/FAK1 cascade, leading to collapse of the neuronal growth cone and neurite outgrowth inhibition.

Conjugation: HRP

Excitation/ Emission: N/A

Size: 100ul

Concentration: Lot dependent

Applications: WB(1:300-5000)

Predicted Molecular Weight: 49

Cross Reactive Species: Human
Mouse
Rat

For research use only. Not intended for diagnostic or therapeutic use.