bsm-62393R

DATASHEET

Host: Rabbit

Target Protein: ERCC8

Clonality: Monoclonal

Isotype: IgG

Entrez Gene: 1161

Swiss Prot: Q13216

Source: KLH conjugated synthetic peptide derived from human ERCC8

Purification: Purified by Protein A.

Storage Buffer: 10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol.

Storage: Shipped at 4°. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Background:

Substrate-recognition component of the CSA complex, a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex, involved in transcription-coupled nucleotide excision repair. The CSA complex (DCX(ERCC8) complex) promotes the ubiquitination and subsequent proteasomal degradation of ERCC6 in a UV-dependent manner; ERCC6 degradation is essential for the recovery of RNA synthesis after transcription-coupled repair.

Size: 100ul

Concentration: 1ug/ul

Predicted Molecular Weight: 44

Cross Reactive Species: Human

For research use only. Not intended for diagnostic or therapeutic use.