bsm-62280R

DATASHEET

Host: Rabbit

Target Protein: PA26

Clonality: Monoclonal

Isotype: IgG

Entrez Gene: 27244

Swiss Prot: Q9Y6P5

Source: KLH conjugated synthetic peptide derived from human Sestrin 1

Purification: Purified by Protein A.

Storage Buffer: 10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol.

Storage: Shipped at 4°. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Background:

Functions as an intracellular leucine sensor that negatively regulates the TORC1 signaling pathway through the GATOR complex. In absence of leucine, binds the GATOR subcomplex GATOR2 and prevents TORC1 signaling. Binding of leucine to SESN2 disrupts its interaction with GATOR2 thereby activating the TORC1 signaling pathway.

Size: 100ul

Concentration: 1ug/ul

Predicted Molecular Weight: 57

Cross Reactive Species: Human
Mouse
Rat

For research use only. Not intended for diagnostic or therapeutic use.