bsm-61914R

DATASHEET

Host: Rabbit

Target Protein: MIB1

Clonality: Recombinant

Isotype: IgG

Entrez Gene: 57534

Swiss Prot: Q86YT6

Source: KLH conjugated synthetic peptide derived from human MIB1

Purification: Purified by Protein A.

Storage Buffer: 10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol.

Storage: Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.

Background:

E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors. Probably mediates ubiquitination and subsequent proteasomal degradation of DAPK1, thereby antagonizing anti-apoptotic effects of DAPK1 to promote TNF-induced apoptosis.

Size: 100ul

Concentration: Lot dependent

Predicted Molecular Weight: 110

Cross Reactive Species: Human
Mouse

For research use only. Not intended for diagnostic or therapeutic use.