bsm-61708R

DATASHEET

Host: Rabbit

Target Protein: MELK

Clonality: Monoclonal

Isotype: IgG

Entrez Gene: 9833

Swiss Prot: Q14680

Source: KLH conjugated synthetic peptide derived from human MELK

Purification: Purified by Protein A.

Storage Buffer: 10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol.

Storage: Shipped at 4°. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Background:

Serine/threonine-protein kinase involved in various processes such as cell cycle regulation, self-renewal of stem cells, apoptosis and splicing regulation. Has a broad substrate specificity; phosphorylates BCL2L14, CDC25B, MAP3K5/ASK1 and ZNF622. Acts as an activator of apoptosis by phosphorylating and activating MAP3K5/ASK1. Acts as a regulator of cell cycle, notably by mediating phosphorylation of CDC25B, promoting localization of CDC25B to the centrosome and the spindle poles during mitosis.

Size: 100ul

Concentration: 1ug/ul

Predicted Molecular Weight: 75

Cross Reactive Species: Human

For research use only. Not intended for diagnostic or therapeutic use.