bsm-61622R-HRP

DATASHEET

Host: Rabbit

Target Protein: CRK (Tyr221)

Modification Site: Tyr221

Clonality: Recombinant

Isotype: IgG

Entrez Gene: 1398

Swiss Prot: P46108

Source: KLH conjugated synthetic peptide derived from human CRK around the phosphorylation site of Y221

Purification: Purified by Protein A.

Storage Buffer: Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Storage: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Background:

The Crk-I and Crk-II forms differ in their biological activities. Crk-II has less transforming activity than Crk-I. Crk-II mediates attachment-induced MAPK8 activation, membrane ruffling and cell motility in a Rac-dependent manner. Involved in phagocytosis of apoptotic cells and cell motility via its interaction with DOCK1 and DOCK4. May regulate the EFNA5-EPHA3 signaling.

Conjugation: HRP

Excitation/ Emission: N/A

Size: 100ul

Concentration: Lot dependent

Applications: WB(1:300-5000)

Predicted Molecular Weight: 34

Cross Reactive Species: Human

For research use only. Not intended for diagnostic or therapeutic use.