bsm-61196R

DATASHEET

Host: Rabbit

Target Protein: beta Arrestin 1

Modification Site: Ser412

Clonality: Monoclonal

Isotype: IgG

Entrez Gene: 408

Swiss Prot: P49407

Source: KLH conjugated synthetic peptide derived from human beta Arrestin 1 around the phosphorylation site of S412

Purification: Purified by Protein A.

Storage Buffer: 10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol.

Storage: Shipped at 4°. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Background:

Functions in regulating agonist-mediated G-protein coupled receptor (GPCR) signaling by mediating both receptor desensitization and resensitization processes. During homologous desensitization, beta-arrestins bind to the GPRK-phosphorylated receptor and sterically preclude its coupling to the cognate G-protein; the binding appears to require additional receptor determinants exposed only in the active receptor conformation.

Size: 100ul

Concentration: 1ug/ul

Predicted Molecular Weight: 47

Cross Reactive Species: Human

For research use only. Not intended for diagnostic or therapeutic use.