bsm-61131R [Primary Antibody]
TRAM2 Recombinant Antibody
www.biossusa.com
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DATASHEET

Host: Rabbit

Target Protein: TRAM2

Clonality: Recombinant

Isotype: IgG

Entrez Gene: 9697

Swiss Prot: Q15035

Source: KLH conjugated synthetic peptide derived from human TRAM2

Purification: Purified by Protein A.

Storage Buffer: 10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol.

Storage: Shipped at 4°. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Background:

Necessary for collagen type I synthesis. May couple the activity of the ER Ca2+ pump SERCA2B with the activity of the translocon. This coupling may increase the local Ca2+ concentration at the site of collagen synthesis, and a high Ca2+ concentration may be necessary for the function of molecular chaperones involved in collagen folding. Required for proper insertion of the first transmembrane helix N-terminus of TM4SF20 into the ER lumen, may act as a ceramide sensor for regulated alternative translocation (RAT).

Size: 100ul

Concentration: Lot dependent

Predicted Molecular Weight: 43


Cross Reactive Species: Human
Mouse
Rat

For research use only. Not intended for diagnostic or therapeutic use.

VALIDATION IMAGES

Western blot analysis of HepG2 cell lysate. Using TRAM2 (bsm-61131R) monoclonal antibody at 1:1000 dilution and 4°C overnight incubation. Followed by conjugated secondary antibody incubation at r.t. for 60 min.