bsm-60239M [Primary Antibody]
ABCA1 Recombinant Antibody
www.biossusa.com
[email protected]
800.501.7654 [DOMESTIC]
+1.781.569.5821 [INTERNATIONAL]
DATASHEET

Host: Mouse

Target Protein: ABCA1

Clonality: Recombinant

Isotype: IgG

Entrez Gene: 19

Swiss Prot: O95477

Source: KLH conjugated synthetic peptide derived from human ABCA1

Purification: Purified by Protein G.

Storage Buffer: 0.01M TBS (pH 7.4), 1% BSA, 0.02% Proclin 300, and 50% Glycerol

Storage: Shipped at 4C. Store at -20C for one year. Avoid repeated freeze/thaw cycles.

Background:

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. With cholesterol as its substrate, this protein functions as a cholesteral efflux pump in the cellular lipid removal pathway. Mutations in both alleles of this gene cause Tangier disease and familial high-density lipoprotein (HDL) deficiency. [provided by RefSeq, Sep 2019]

Size: 100ul

Concentration: 1mg/ml

Applications: WB=1:500-2000
ICC=1:100-500
IF=1:100-500

Predicted Molecular Weight: 254


Cross Reactive Species: Mouse

For research use only. Not intended for diagnostic or therapeutic use.

PRODUCT SPECIFIC PUBLICATIONS
  • Chun-xia Nie. et al. Shenlian extract protected ox-LDL-loaded macrophages against ER stress by promoting LAL-LXR mediated cholesterol flux. J ETHNOPHARMACOL. 2023 Jun;:116721Read more>>
  • Yueqi Cui. et al. The activation of liver X receptors in Madin-Darby bovine kidney cells and mice restricts infection by bovine viral diarrhea virus. VET MICROBIOL. 2023 Dec;:109948Read more>>
VALIDATION IMAGES

Blocking buffer: 5% NFDM/TBST Primary ab dilution: 1:2000 Primary ab incubation condition: 2 hours at room temperature Lysate: Mouse liver Protein loading quantity: 20 μg Exposure time: 180 S Predicted MW: 254 kDa Observed MW: 254 kDa