bsm-52752R
[Primary Antibody]
LC3B (1C4) Monoclonal Antibody
DATASHEET
Host: Rabbit
Target Protein: LC3B
Clonality: Monoclonal
Isotype: IgG
Entrez Gene: 81631
Swiss Prot: Q9GZQ8
Source: Recombinant protein
Purification: Purified by Protein A.
Storage Buffer: 0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Storage: Store at -20°C for 12 months.
Background:
Ubiquitin-like modifier involved in formation of autophagosomal vacuoles (autophagosomes). Plays a role in mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation. Promotes primary ciliogenesis by removing OFD1 from centriolar satellites via the autophagic pathway.
Size: 100ul
Concentration: 1ug/ul
Cross Reactive Species:
Human
Mouse
Rat
For research use only. Not intended for diagnostic or therapeutic use.
VALIDATION IMAGES
Lane 1: Hela Cells; Lane 2: MCF-7 Cells; Probed with LC3B (1C4) Monoclonal Antibody (bsm-52752R) at 1:1000 overnight at 4°C followed by a conjugated secondary antibody for 60 minutes at 37°C.