bsm-52507R [Primary Antibody]
Tau (Thr231) (13D4) Monoclonal Antibody
www.biossusa.com
[email protected]
800.501.7654 [DOMESTIC]
+1.781.569.5821 [INTERNATIONAL]
DATASHEET

Host: Rabbit

Target Protein: Tau (T231)

Modification Site: Thr231

Clonality: Monoclonal

Isotype: IgG

Entrez Gene: 4137

Swiss Prot: P10636

Source: Synthetic phospho-peptide surrounding Thr231 of human Tau

Purification: Purified by Protein A.

Storage Buffer: 0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Storage: Store at -20°C for 12 months.

Background:

Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.

Size: 100ul

Concentration: 1ug/ul

Cross Reactive Species: Human
Mouse
Rat

For research use only. Not intended for diagnostic or therapeutic use.

VALIDATION IMAGES

Mouse Brain lysate probed with Tau (Thr231) (13D4) Monoclonal Antibody (bsm-52507R) at 1:1000 overnight at 4°C followed by a conjugated secondary antibody for 60 minutes at 37°C.