Host: Mouse
Target Protein: SIGLEC15
Clonality: Monoclonal
Isotype: IgG
Entrez Gene: 284266
Swiss Prot: Q6ZMC9
Source: Recombinant human SIGLEC15 protein
Purification: Purified by Protein A.
Storage Buffer: Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Storage: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
Background:
Two families of mammalian lectin-like adhesion molecules, the selectins and the sialoadhesins, bind glycoconjugate ligands in a sialic acid-dependent manner. The sialic acid-binding immunoglobulin superfamily lectins, designated Siglecs or sialoadhesins, recognize sialylated ligands and play a key role in mediating sialic-acid dependent binding to cells. Siglec-15 (sialic acid binding Ig-like lectin 15), also known as CD33L3, is a 328 amino acid single-pass type I membrane protein that contains one Ig-like C2-type domain and one Ig-like V-type domain. Expressed in dendritic and macrophage cells, Sinlec-15 interacts with DAP10 and DAP12 and binds to sialylated glycoproteins. The gene encoding Siglec-15 maps to human chromosome 18, which houses over 300 protein-coding genes and contains nearly 76 million bases.
Conjugation: AbBy Fluor® 680
Excitation/ Emission: 679nm/702nm
Size: 100ul
Concentration: 1ug/ul
Applications: WB()
Predicted Molecular Weight: 34
Cross Reactive Species: Human
For research use only. Not intended for diagnostic or therapeutic use.