DATASHEET
Host:
Mouse
Target Protein:
H-2 class I histocompatibility antigen, K-K alpha chain
Clonality:
Monoclonal
Isotype:
IgG2a/Kappa
Entrez Gene:
14972
Swiss Prot:
P04223
Purification:
Affinity purified by Protein G
Storage Buffer:
0.01M PBS, 0.5%BSA, 0.02% Proclin300
Storage:
Store at 2-8℃. Protect from light. Avoid freezing.
Background:
Enables MHC class I protein binding activity and peptide antigen binding activity. Acts upstream of or within several processes, including antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent; antigen processing and presentation of exogenous peptide antigen via MHC class I; and positive regulation of T cell mediated cytotoxicity. Located in external side of plasma membrane. Is expressed in several structures, including brain; genitourinary system; hemolymphoid system gland; liver; and retina. Used to study myositis. Human ortholog(s) of this gene implicated in several diseases, including asthma (multiple); autoimmune disease (multiple); eye disease (multiple); human immunodeficiency virus infectious disease (multiple); and inner ear disease (multiple). Orthologous to several human genes including HLA-A (major histocompatibility complex, class I, A); HLA-E (major histocompatibility complex, class I, E); and HLA-F (major histocompatibility complex, class I, F). [provided by Alliance of Genome Resources, Apr 2022]