bsm-10841M-HRP

DATASHEET

Host: Mouse

Target Protein: TP53

Clonality: Monoclonal

Isotype: IgG

Entrez Gene: 7157

Swiss Prot: P04637

Source: Recombinant human P53 protein (C-His-Tag)

Purification: Purified by Protein A.

Storage Buffer: Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Storage: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Background:

Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Implicated in Notch signaling cross-over. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression. Isoform 2 enhances the transactivation activity of isoform 1 from some but not all TP53-inducible promoters. Isoform 4 suppresses transactivation activity and impairs growth suppression mediated by isoform 1. Isoform 7 inhibits isoform 1-mediated apoptosis.

Conjugation: HRP

Excitation/ Emission: N/A

Size: 100ul

Concentration: 1mg/ml

Applications: ELISA(1:500-1000)
IHC-P(1:200-400)

Predicted Molecular Weight: 43

Cross Reactive Species: Human

For research use only. Not intended for diagnostic or therapeutic use.