bs-9515R [Primary Antibody]
CTH Polyclonal Antibody
www.biossusa.com
[email protected]
800.501.7654 [DOMESTIC]
+1.781.569.5821 [INTERNATIONAL]
DATASHEET

Host: Rabbit

Target Protein: CTH

Immunogen Range: 51-150/405


Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 1491

Source: KLH conjugated synthetic peptide derived from human Cystathionine gamma lyase

Purification: Purified by Protein A.

Storage Buffer: 0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Storage: Shipped at 4C. Store at -20C for one year. Avoid repeated freeze/thaw cycles.

Background:

Catalyzes the last step in the transsulfuration pathway from methionine to cysteine. Has broad substrate specificity. Converts cystathionine to cysteine, ammonia and 2-oxobutanoate. Converts two cysteine molecules to lanthionine and hydrogen sulfide. Can also accept homocysteine as substrate. Specificity depends on the levels of the endogenous substrates. Generates the endogenous signaling molecule hydrogen sulfide (H2S), and so contributes to the regulation of blood pressure.Defects in CTH are the cause of cystathioninuria (CSTNU). It is an autosomal recessive phenotype characterized by abnormal accumulation of plasma cystathionine, leading to increased urinary excretion.

Size: 100ul

Concentration: 1ug/ul

Applications: WB(1:300-5000)
IHC-P(1:200-400)
IF(IHC-P)(1:50-200)

Cross Reactive Species: Human
Mouse

Predicted Cross Reactive Species: Rat
Dog
Cow
Rabbit

For research use only. Not intended for diagnostic or therapeutic use.

PRODUCT SPECIFIC PUBLICATIONS
  • Shiina, Takahiko, et al. "Inhibitory action of hydrogen sulfide on esophageal striated muscle motility in rats." European Journal of Pharmacology (2016).Read more>>
  • Heng-Jing Hu. et al. Hydrogen sulfide improves ox?LDL?induced expression levels of Lp?PLA<sub>2</sub> in THP?1 monocytes via the p38MAPK pathway. Mol Med Rep. 2021 May;23(5):1-1Read more>>
  • Heng-Jing Hu. et al. Hydrogen Sulfide Ameliorates Angiotensin II-Induced Atrial Fibrosis Progression to Atrial Fibrillation Through Inhibition of the Warburg Effect and Endoplasmic Reticulum Stress. Front Pharmacol. 2021 Dec 7;12:690371Read more>>
  • Xiaoyan Zheng. et al. Novel findings from arsenic?lead combined exposure in mouse testicular TM4 Sertoli cells based on transcriptomics. SCI TOTAL ENVIRON. 2023 Dec;:169611Read more>>
  • ao Yuan. et al. Exploring the Mechanism of H2S Synthesis in Male Bactrian Camel Poll Glands Based on Data Independent Acquisition Proteomics and Non-Targeted Metabolomics. INT J MOL SCI. 2024 Jul; 25(14): 77Read more>>
VALIDATION IMAGES

Lane 1: Mouse liver lysates probed with CTH Polyclonal Antibody, Unconjugated (bs-9515R) at 1:300 overnight at 4˚C. Followed by a conjugated secondary antibody at 1:20000 for 60 min at 37˚C.


Lane 1: K562 lysates probed with CTH Polyclonal Antibody, Unconjugated (bs-9515R) at 1:300 overnight at 4˚C. Followed by a conjugated secondary antibody at 1:20000 for 60 min at 37˚C.