bs-83447C
[Life Science]
10074-G5
DATASHEET
Formulation Orange solid
Storage: -20°C
Product Information:
Inhibits c-Myc by disrupting c-Myc/Max heterodimer formation and inhibiting its transcriptional activity.1 10074-G5 binds to the c-Myc bHLHZip domain with Kd=2.8 mM.1 It was cytotoxic in C-Myc-overexpressing cell lines (IC50s = 13 to 15 mM) but was not active in vivo due to rapid metabolism.2 10074-G5 is a useful tool to probe for involvement of c-Myc involvement in cellular processes.3,4 Binds to and sequesters the intrinsically disordered amyloid-β (Aβ) in its monomeric soluble state and rescues a C. elegans model of Aβ-associated toxicity.5
Description:
CAS Number: 413611-93-5<br></br>Chemical Name: c-Myc inhibitor<br></br>Molecular Weight: 332.32<br></br>Formula: C18H12N4O3<br></br>Solubility: DMSO (40 mg/ml)<br></br>Physical Properties: Orange solid<br></br>Purity: 98% by TLC NMR (Conforms)
Size: 25mg,5mg
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.