bs-83130C
[Life Science]
AR7
DATASHEET
Formulation Off-white solid
Storage: -20°C
Product Information:
Atypical retinoid which acts as an RARα antagonist and activates chaperone-mediated autophagy (CMA) via an RAR-dependent pathway.1 Downstream signaling results in an increase of LAMP-2A expression.1 Cells pretreated with AR7 had markedly improved viability in a paraquat-induced oxidative stress model.1 AR7 stimulated CMA and attenuated accumulation of SNCA oligomers in prolonged cultures of mutant cortical neurons2 indicating that CMA activation may be a viable disease modifying strategy in Parkinson’s disease3. A targetome analysis of AR7-induced CMA in cancer cells has been performed.4
Description:
CAS Number: 80306-38-3<br></br>Chemical Name: 7-Chloro-3-(4-methylphenyl)-2H-1,4-benzoxazine<br></br>Molecular weight: 257.72<br></br>Formula: C15H12ClNO<br></br>Solubility: DMSO (30 mg/ml)<br></br>Physical Properties: Pale pink solid<br></br>Purity: 98% by TLC NMR (Conforms)
Size: 5 mg, 25 mg5 mg, 25 mg
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.