bs-83126C
[Life Science]
GSK4112
DATASHEET
Formulation Off-white solid
Storage: -20°C
Product Information:
Selective Rev-Erbα agonist (EC50=250 nM).1,2 It induces circadian clock phase shifts in isolated primary lung fibroblasts as well as in lung slices (10 µM).1 GSK4112 showed an inhibitory effect on the amplitude of circadian oscillations and caused an arrhythmic expression of canonical clock genes.3 In murine RAW264 macrophages it suppressed inflammatory functions via repressing Ccl2 expression.4 It protected RANKL-induced bone loss via inhibition of osteoclast differentiation in vivo.5
Description:
CAS Number: 1216744-19-2<br></br>Chemical Name: N-[(4-Chlorophenyl)methyl]-N-[(5-nitro-2-thienyl)methyl]glycine, 1,1-dimethyl ester<br></br>Molecular weight: 396.89<br></br>Formula: C18H21ClN2O4S<br></br>Solubility: DMSO (50 mg/mL)<br></br>Physical Properties: White solid<br></br>Purity: >98% by HPLC NMR (Conforms)
Size: 5 mg, 25 mg5 mg, 25 mg
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.