bs-83122C
[Life Science]
SM-164
DATASHEET
Formulation White solid
Storage: -20°C
Product Information:
Cell-permeable Smac (DIABLO) mimetic that inhibits caspase blockers XIAP, cIAP1, and cIAP2 (Ki = 36, <1, and <1.9 nM), thus inducing apoptosis.1-3 SM-164 sensitizes cancer cells to DNA damaging agents.4 It also prevents binding of Hsp70 to XIAP.5 At high concentrations, it causes lytic cell death that is neither apoptosis nor necroptosis.6
Description:
CAS Number: 957135-43-2<br></br>Chemical Name: (3S,3′S,6S,6′S,10aS,10′aS)-N,N′-[1,4-phenylenebis[4,1-butanediyl-1H-1,2,3-triazole-1,4-diyl[(S)-phenylmethylene]]]bis[decahydro-6-[[(2S)-2-(methylamino)-1-oxopropyl]amino]-5-oxo-pyrrolo[1,2-a]azocine-3-carboxamide<br></br>Molecular weight: 1121.45<br></br>Formula: C62H84N14O6<br></br>Solubility: DMSO (50 mg/ml)<br></br>Physical Properties: White to pale-yellow solid<br></br>Purity: 98% by HPLC NMR (Conforms)
Size: 1 mg, 5 mg 5 mg
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.