bs-83121C
[Life Science]
CDDO-Me
DATASHEET
Formulation White solid
Storage: -20°C
Product Information:
Potent activator of Nrf2 target transcription via interaction with thiol groups of Keap1, an Nrf2 partner, in phase 2 response against oxidative stress.1 Inhibits the NF-κB pathway via inhibition of IKKα activation in vitro2 and reduces expression of proinflammatory cytokines in vivo3. Alters tumor microenvironment causing breast tumor associated macrophages to switch from tumor-promoting to tumor-inhibiting characteristics in vitro.4 Reduces cancer stem cell marker expression in Ec109 and KYSE70 cells.5
Description:
CAS Number: 218600-53-4<br></br>Chemical Name: 2-Cyano-3,12-dioxooleana-1,9(11)-dien-28-oic acid methyl ester<br></br>Molecular weight: 505.7<br></br>Formula: C32H43NO4<br></br>Solubility: Soluble in DMSO (25 mg/ml with warming)<br></br>Physical Properties: White solid<br></br>Purity: >98% by HPLC NMR (Conforms)
Size: 5 mg, 25 mg5 mg, 25 mg
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.