bs-83100C
[Life Science]
OSS-128167
DATASHEET
Formulation Pink solid
Storage: -20°C
Product Information:
OSS-128167 (887686-02-4) is an inhibitor of SIRT6 (IC50=89 µM) showing selectivity over SIRT1 and SIRT2 (IC50s=1,578 and 751 µM, respectively).1 In diffuse large B-cell lymphoma cells which overexpress SIRT6, treatment with OSS-128167 resulted in higher rates of apoptosis, arrested cell cycle progression and augmented sensitivity to chemotherapy.2 It exacerbates diabetic cardiomyopathy by aggravating inflammation and oxidative stress in a streptozotocin-induced diabetic mouse model3 and delays peripheral nerve recovery after injury by suppressing migration, phagocytosis and M2-polarization of macrophages4. OSS-128167 promotes cell senescence and aging in myocardial H9c2 cells.5
Description:
CAS Number: 887686-02-4<br></br>Chemical Name: 5-(3-(Furan-2-carboxamido)benzamido)-2-hydroxybenzoic acid<br></br>Molecular weight: 366.66<br></br>Formula: C19H14N2O6<br></br>Solubility: DMSO (25 mg/ml) Ethanol (25 mg/ml)<br></br>Physical Properties: Off-white solid<br></br>Purity: >98% by TLC NMR (Conforms)
Size: 25mg,5mg
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.