bs-83087C
[Life Science]
Remodelin
DATASHEET
Formulation Off white or yellow solid
Storage: -20°C
Product Information:
Potent and selective inhibitor of N-acetyltransferase 10 (NAT10) which is capable of acetylating microtubules and histones.1 Improves nuclear architecture, chromatin organization and fitness of both human lamin A/C-depleted cells and Hutchinson-Gilford progeria syndrome patient cells1, normalizing progeric and aging cells2. Enhances health span in a mouse model of human accelerated aging syndrome.3 Significantly reduces many of the defects associated with accumulation of the lamin A precursor, prelamin A.4 Inhibits NAT10-promoted metastasis which may be mediated by endothelial-to-mesenchymal transition in hepatocellular carcinoma.5
Description:
CAS Number: 949912-58-7<br></br>Chemical Name: 4-[2-(2-cyclopentylidenehydrazinyl)-4-thiazolyl]-benzonitrile<br></br>Molecular weight: 282.36<br></br>Formula: C15H14N4S<br></br>Solubility: DMSO (40 mg/ml)<br></br>Physical Properties: Pale yellow solid<br></br>Purity: 98% by HPLC NMR (conforms)
Size: 5 mg, 25 mg5 mg, 25 mg
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.