bs-83082C
[Life Science]
Fludarabine
DATASHEET
Formulation Colorless to pale yellow oil
Storage: -20°C
Product Information:
A synthetic adenosine analog that inhibits DNA biosynthesis and is a clinically useful antineoplastic agent.1 In cells fludarabine accumulates as its 5’-triphosphate (F-ara-ATP) for which the rate-limiting step in formation is the conversion of fludarabine to its monophosphate.2 F-ara-ATP has multiple mechanisms of action including inhibition of ribonucleotide reductase, DNA polymerase, ligase and primase.2 A frequently used agent in myeloablative conditioning regimens for allogeneic hematopoietic cell transplantation.3 Immunosuppressive effects are mediated via inhibition of TNF-stimulated production of IL-2 and IFN- through inactivation of NFB.4 Antagonist at adenosine A1 receptors.5
Description:
CAS Number: 21679-14-1<br></br>Chemical Name: 9-β-D-Arabinofuranosyl-2-fluoro-9H-purin-6-amine;<br></br>Molecular weight: 285.23<br></br>Formula: C10H12FN5O4<br></br>Solubility: DMSO (30 mg/ml)<br></br>Physical Properties: White solid<br></br>Purity: 98% by HPLC NMR (Conforms)
Size: 10 mg, 50 mg10 mg, 50 mg
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.