bs-83082C

DATASHEET

Formulation Colorless to pale yellow oil

Storage: -20°C

Product Information:

A synthetic adenosine analog that inhibits DNA biosynthesis and is a clinically useful antineoplastic agent.1 In cells fludarabine accumulates as its 5’-triphosphate (F-ara-ATP) for which the rate-limiting step in formation is the conversion of fludarabine to its monophosphate.2 F-ara-ATP has multiple mechanisms of action including inhibition of ribonucleotide reductase, DNA polymerase, ligase and primase.2 A frequently used agent in myeloablative conditioning regimens for allogeneic hematopoietic cell transplantation.3 Immunosuppressive effects are mediated via inhibition of TNF-stimulated production of IL-2 and IFN- through inactivation of NFB.4 Antagonist at adenosine A1 receptors.5

Description:

CAS Number: 21679-14-1 Chemical Name: 9-β-D-Arabinofuranosyl-2-fluoro-9H-purin-6-amine; Molecular weight: 285.23 Formula: C10H12FN5O4 Solubility: DMSO (30 mg/ml) Physical Properties: White solid Purity: 98% by HPLC NMR (Conforms)