bs-83069C
[Life Science]
Olodanrigan
DATASHEET
Formulation Orange solid
Storage: -20°C
Product Information:
Potent (IC50 = 39.5 nM) and selective (>10,000-fold selectivity AT2R/AT1R) antagonist of the angiotensin II type 2 receptor.1 It produced dose-dependent relief of hindpaw sensitivity in a rat model of neuropathic pain1 and showed efficacy in a human trial against postherpetic neuralgia2. Olodanrigan prevented paclitaxel-associated acute pain syndrome in mice.3 It blocked visceral hypersensitivity and colonic hyperpermeability in a rat model of irritable bowel syndrome.4 It was also able to inhibit proliferation of AT2R-expressing glioblastoma spheroids and blocked their invasiveness and angiogenic capability.5
Description:
CAS Number: 1316755-16-4<br></br>Chemical Name: (S)-Benzyloxy-2-diphenylacetyl-6-methoxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid<br></br>Molecular weight: 507.59<br></br>Formula: C32H29NO5<br></br>Solubility: DMSO (>35 mg/ml)<br></br>Physical Properties: Off-white solid<br></br>Purity: >98% by HPLC (NMR Conforms)
Size: 5 mg, 25 mg5 mg, 25 mg
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.