bs-83059C
[Life Science]
Chroman 1
DATASHEET
Formulation White solid
Storage: -20°C
Product Information:
Extremely potent inhibitor of Rho kinase II (ROCK-II)1,2 – it displayed greater selectivity and potency compared to Y-27632 (IC50’s: ROCK I = 52 pM/ROCK II = 1 pM; Y-27632 IC50’s: ROCK I = 71 nM/ROCK II = 46 nM)3. Chroman 1, used in conjunction with trans-ISRIB (Cat# 10-1539), Emricasan (Cat# 10-4280), and polyamines (CEPT cocktail), promotes cytoprotective cell survival in human pluripotent stem cells (hPSCs) and was found to superior to Y-27632.3 Chroman 1 is an important new tool in the generation and maintenance of stem cells.
Description:
CAS Number: 1273579-40-0<br></br>Chemical Name: (3S)-N-[2,[2-(Dimethylamino)ethoxy)-4-(1H-pyrazol-4-yl)phenyl]-6-methoxy-3,4-dihydro-2H-chromen-3-carboxamide<br></br>Molecular weight: 436.51<br></br>Formula: C24H28N4O4<br></br>Solubility: DMSO (>50 mg/ml)<br></br>Physical Properties: White solid<br></br>Purity: 99% by HPLC NMR (conforms)
Size: 1 mg, 5 mg 5 mg
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.