bs-83051C
[Life Science]
UNC0379
DATASHEET
Formulation Off-white or pale yellow solid
Storage: -20°C
Product Information:
UNC0379 is an inhibitor of the lysine methyltransferase SETD8 with selectivity over 15 other methyltransferases.1 IC50’s = 7.3 µM in a radioactive methyl transfer assay and 9.0 µM in an MCE assay. UNC0379 treatment of SY5Y and NGP neuroblastoma cell lines lead to activation of p53 and decreased tumor growth in an ex-vivo tumorigenicity assay.2
Description:
CAS Number: 1620401-82-2<br></br>Chemical Name: 6,7-Dimethoxy-2-(pyrrolidin-1-yl)-N-(5-(pyrrolidin-1-yl)-pentyl)quinazolin-4-amine<br></br>Molecular weight: 413.56<br></br>Formula: C23H35N5O2<br></br>Solubility: DMSO (>30 mg/ml)<br></br>Physical Properties: Tan solid<br></br>Purity: 98% by TLC NMR (Conforms)
Size: 5 mg, 25 mg5 mg, 25 mg
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.